Consignment and thrift are two different models. At a consignment shop, you bring in your items, the store sells them on your behalf, and you split the revenue. The typical seller cut runs 50% to 60% of the final price.
Thrift stores work differently. They accept donations at no cost, price everything low, and keep all proceeds. Goodwill and Salvation Army are the biggest US examples. You walk out with a $5 flannel shirt. Nobody gets a payout.
I've shopped both extensively across the US. Consignment shops in cities like LA and Chicago tend to curate carefully. Every item on the floor passed an inspection. Thrift stores take volume over curation.
The practical difference: bring your quality pieces to consignment if you want to earn. Go thrift if you want to buy cheap.